Products for Research Use Only
RegisterLogin

Ro 25-6981

CAT: 0804-HY-13993-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13993-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD) [1][2][3].
CAS Number
169274-78-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-25-6981.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C([C@H](O)[C@@H](C)CN2CCC(CC3=CC=CC=C3)CC2)C=C1
Molecular Formula
C22H29NO2
Molecular Weight
339.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Löschmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp Neurol. 2004 May;187 (1) :86-93.|[2]Szczurowska E, et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. |[3]Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Citation 01
Cell Death Differ. 2023 Jul;30 (7) :1726-1741.|CNS Neurosci Ther. 2023 May;29 (5) :1229-1242.|Exp Brain Res. 2023 Dec;241 (11-12) :2735-2750.|Neurobiol Dis. 2025 Oct 15:215:107090.|Neuropharmacology. 2022 Mar 15:206:108947.|Neurochem Int. 2021 Feb:143:104942.|Sci Rep. 2022 Oct 12;12 (1) :17114.

Related Products

CatalogName
HY-P10768Ro 25-1553
HY-125579-01Ro 25-0534
HY-R03693-01Mmu-miR-6981-5p mimic
HY-R03692-01Mmu-miR-6981-3p mimic
HY-RI03692A-01Mmu-miR-6981-3p antagomir
HY-R03692A-01Mmu-miR-6981-3p agomir
HY-R03693A-01Mmu-miR-6981-5p agomir
HY-RI03693A-01Mmu-miR-6981-5p antagomir
HY-RI03693-01Mmu-miR-6981-5p inhibitor
HY-RI03692-01Mmu-miR-6981-3p inhibitor

Alternative Products

CatalogName
M26420-01Ro 25-6981
M33109-01Ro 25-6981 Maleate
A13144-2Ro 25-6981 2mg
A13144-1Ro 25-6981 1mg
T24717-01Ro 25-6981 HCl
A13144-100Ro 25-6981 100mg
A13144-50Ro 25-6981 50mg
A13144-25Ro 25-6981 25mg

Popular Products