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SPARC

CAT: 0579-X1855BSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0579-X1855BSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and _x000B_fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 -UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer._x000B__x000B_SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).
Synonyms
Secreted Protein Acidic and Rich in Cysteine, Secreted modular calcium-Binding Protein 2, SMOC-2, Smooth muscle-associated Protein 2, SMAP-2
UniProt
Q9H3U7
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
Functional Inhibition
Field of Research
Signal Transduction
Assay Principle
Blocking peptide for use with SPARC antibodies (Cat. Nos. X1860P , X1867P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
Antibody Function Blocking

Alternative Products

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abx241923-01SPARC (SPARC) Antibody
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MBS950314-01Recombinant Pig SPARC (SPARC)
MBS949227-01Recombinant Chicken SPARC (SPARC)
MBS1143682-01Recombinant Rat SPARC (Sparc)
AP72077-01Recombinant Human SPARC(SPARC)
MBS966260-01Recombinant Mouse SPARC (Sparc)
MBS954463-01Recombinant Rabbit SPARC (SPARC)
377604SPARC

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