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Gnetol

CAT: 0804-HY-126052-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126052-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities[1][2][3].
CAS Number
86361-55-9
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
COX; HDAC; Tyrosinase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gnetol.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(O)=C1/C=C/C2=CC(O)=CC(O)=C2
Molecular Formula
C14H12O4
Molecular Weight
244.24
Precautions
H315, H319, H335
References & Citations
[1]Remsberg CM, et al. Preclinical Pharmacokinetics and Pharmacodynamics and Content Analysis of Gnetol in Foodstuffs. Phytother Res. 2015 Aug;29 (8) :1168-79.|[2]Ohguchi K, et al. Gnetol as a potent tyrosinase inhibitor from genus Gnetum. Biosci Biotechnol Biochem. 2003 Mar;67 (3) :663-5.|[3]Jinadatta P, et al. In silico, in vitro: antioxidant and antihepatotoxic activity of gnetol from Gnetum ula Brongn. Bioimpacts. 2019;9 (4) :239-249.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1

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