Products for Research Use Only
RegisterLogin

Vibegron

CAT: 0804-HY-19933-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-19933-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Vibegron (MK-4618) is a potent, highly selective and orally active β3-adrenoceptor agonist (EC50=1.1 nM) . Vibegron can be used for severe urgency urinary incontinence related to overactive bladder[1][2][3].
CAS Number
1190389-15-1
Product Name Alternative
MK-4618
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vibegron.html
Concentration
10mM
Purity
98.03
Solubility
DMSO : 95 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CCC2=NC=CC(N21)=O)NC3=CC=C(C[C@H]4N[C@@H]([C@H](O)C5=CC=CC=C5)CC4)C=C3
Molecular Formula
C26H28N4O3
Molecular Weight
444.53
Precautions
H315, H319, H320
References & Citations
[1]Yoshida M, et al. Efficacy of vibegron, a novel β3-adrenoreceptor agonist, on severe urgency urinary incontinence related to overactive bladder: post hoc analysis of a randomized, placebo-controlled, double-blind, comparative phase 3 study. BJU Int. 2020;125 (5) :709-717.|[2]Yoshida M, et al. Efficacy of novel β3 -adrenoreceptor agonist vibegron on nocturia in patients with overactive bladder: A post-hoc analysis of a randomized, double-blind, placebo-controlled phase 3 study. Int J Urol. 2019;26 (3) :369-375.|[3]Edmondson SD, et al. Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder. J Med Chem. 2016;59 (2) :609-623.|[4]Gotoh D, et al. Effects of a new β3-adrenoceptor agonist, vibegron, on neurogenic bladder dysfunction and remodeling in mice with spinal cord injury. Neurourol Urodyn. 2020;39 (8) :2120-2127.|[5]Furuta A, et al. Additive effects of intravenous and intravesical application of vibegron, a β3-adrenoceptor agonist, on bladder function in rats with bladder overactivity. Naunyn Schmiedebergs Arch Pharmacol. 2020;393 (11) :2073-2080.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β adrenergic receptor

Alternative Products

CatalogName
MBS5784534Vibegron
CS-O-45402(R) -Vibegron
AR-V06547-01Vibegron-d4
AR-V06548-01Ent-Vibegron
CS-T-103585Vibegron-d5
CS-SN-00170Vibegron 13C5
CS-O-59547Vibegron Epimer
V851963Vibegron 13CD4
CS-O-44706Vibegron impurity 3
CS-O-49928-10MGN-nitroso vibegron

Popular Products