Vibegron

• Description :

  Vibegron (MK-4618) is a potent, highly selective and orally active β3-adrenoceptor agonist (EC50=1.1 nM) . Vibegron can be used for severe urgency urinary incontinence related to overactive bladder[1][2][3].

• Product Name Alternative :

  MK-4618

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/vibegron.html

• Concentration :

  10mM

• Purity :

  98.03

• Solubility :

  DMSO : 95 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H]1CCC2=NC=CC(N21)=O)NC3=CC=C(C[C@H]4N[C@@H]([C@H](O)C5=CC=CC=C5)CC4)C=C3

• Molecular Formula :

  C26H28N4O3

• Molecular Weight :

  444.53

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Yoshida M, et al. Efficacy of vibegron, a novel β3-adrenoreceptor agonist, on severe urgency urinary incontinence related to overactive bladder: post hoc analysis of a randomized, placebo-controlled, double-blind, comparative phase 3 study. BJU Int. 2020;125 (5) :709-717.|[2]Yoshida M, et al. Efficacy of novel β3 -adrenoreceptor agonist vibegron on nocturia in patients with overactive bladder: A post-hoc analysis of a randomized, double-blind, placebo-controlled phase 3 study. Int J Urol. 2019;26 (3) :369-375.|[3]Edmondson SD, et al. Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder. J Med Chem. 2016;59 (2) :609-623.|[4]Gotoh D, et al. Effects of a new β3-adrenoceptor agonist, vibegron, on neurogenic bladder dysfunction and remodeling in mice with spinal cord injury. Neurourol Urodyn. 2020;39 (8) :2120-2127.|[5]Furuta A, et al. Additive effects of intravenous and intravesical application of vibegron, a β3-adrenoceptor agonist, on bladder function in rats with bladder overactivity. Naunyn Schmiedebergs Arch Pharmacol. 2020;393 (11) :2073-2080.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  β adrenergic receptor

• CAS Number :

  [1190389-15-1]