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Aleglitazar

CAT: 0804-HY-14728-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14728-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes[1].
CAS Number
475479-34-6
Product Name Alternative
R1439; RO0728804
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/aleglitazar.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CC1=C(CCOC2=CC=C(C[C@@H](C(O)=O)OC)C3=C2C=CS3)N=C(C4=CC=CC=C4)O1
Molecular Formula
C24H23NO5S
Molecular Weight
437.51
Precautions
H302, H312, H315, H319
References & Citations
[1]Bénardeau A, Benz J, Binggeli A, et al. Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. Bioorg Med Chem Lett. 2009 May 1;19 (9) :2468-73.|[2]Yan Chen, et al. Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia. Diab Vasc Dis Res. 2017 Mar; 14 (2) : 152–162.|[3]Valérie Boujon, et al. Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice. J Mol Med (Berl) . 2019; 97 (8) : 1127-1138.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PPARα; PPARγ

Alternative Products

CatalogName
T14176-01Aleglitazar
A12492-25Aleglitazar 25mg
A12492-50Aleglitazar 50mg
A12492-100Aleglitazar 100mg
A12492-10Aleglitazar 10mg
A12492-5Aleglitazar 5mg
A12492-1Aleglitazar 1mg
A12492-10mM-DAleglitazar 10mM * 1mL in DMSO

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