Copanlisib (Standard)

• Description :

  Copanlisib (Standard) is the analytical standard of Copanlisib. This product is intended for research and analytical applications. Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity[1].

• Product Name Alternative :

  BAY 80-6946 (Standard)

• UNSPSC :

  12352005

• Target :

  Apoptosis; PI3K; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  Apoptosis; Others; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/copanlisib-standard.html

• Smiles :

  O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25

• Molecular Formula :

  C23H28N8O4

• Molecular Weight :

  480.52

• References & Citations :

  [1]Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12 (11) :2319-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [1032568-63-0]