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Neopterin

CAT: 0804-HY-W040055-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W040055-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neopterin is an immune system activator metabolized by GTP and can be produced by activated macrophages. Neopterin has the potential to resist vascular inflammation and atherosclerosis. Neopterin inhibits the phosphorylation of NF-κB and promotes the expression of PPAR-γ, thereby suppressing the inflammatory response of vascular endothelial cells, reducing the formation of macrophage foam cells, and regulating the migration and proliferation of vascular smooth muscle cells. Neopterin can be used in research fields such as cardiovascular diseases (such as atherosclerosis), inflammation-related diseases and tumor immunomonitoring[1][2][3][4][5].
CAS Number
2009-64-5
Product Name Alternative
D- (+) -Neopterin; D-erythro-Neopterin
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
ERK; NF-κB; PPAR; Raf; Src
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/D-__addition__-Neopterin.html
Purity
99.90
Solubility
DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C2C(N=CC([C@H](O)[C@H](O)CO)=N2)=NC(N)=N1
Molecular Formula
C9H11N5O4
Molecular Weight
253.21
Precautions
H315, H319, H335
References & Citations
[1]Shirai R, et al. Neopterin Counters Vascular Inflammation and Atherosclerosis. J Am Heart Assoc. 2018 Feb 2;7 (3) :e007359.|[2]Aisaki K, et al. Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment. Exp Biol Med (Maywood) . 2012 Mar;237 (3) :279-86.|[3]Fuchs D, et al. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases. Crit Rev Clin Lab Sci. 1992;29 (3-4) :307-41.|[4]Sucher R, et al. Neopterin, a prognostic marker in human malignancies. Cancer Lett. 2010 Jan 1;287 (1) :13-22.|[5]Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3 (2) :175-187].
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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