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Adapalene (Standard)

CAT: 0804-HY-B0091R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0091R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Adapalene (Standard) is the analytical standard of Adapalene. This product is intended for research and analytical applications. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3].
CAS Number
106685-40-9
Product Name Alternative
CD271 (Standard)
UNSPSC
12352005
Target
Apoptosis; Autophagy; RAR/RXR; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/adapalene-standard.html
Smiles
COC1=C(C23CC4CC(C3)CC(C2)C4)C=C(C5=CC6=C(C=C(C(O)=O)C=C6)C=C5)C=C1
Molecular Formula
C28H28O3
Molecular Weight
412.52
References & Citations
[1]Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36 (6 Pt 2) :S96-103.|[2]Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315.|[3]Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12 (5) :6501-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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