Ebelactone A

• Description :

  Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively[1]. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis[2].

• UNSPSC :

  12352005

• Target :

  Lipase; MetAP

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Others

• Assay Protocol :

  https://www.medchemexpress.com/ebelactone-a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC[C@@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C[C@@H]([C@@]1([H])[C@@H](C(O1)=O)C)C)=O

• Molecular Formula :

  C20H34O4

• Molecular Weight :

  338.48

• References & Citations :

  [1]Umezawa H, et al., Ebelactone, an inhibitor of esterase, produced by actinomycetes. J Antibiot (Tokyo) . 1980 Dec;33 (12) :1594-6.|[2]Francis S A, et al., The role of cutinase in germling development and infection byErysiphe graminisf. sp. hordei[J]. Physiological and Molecular Plant Pathology, 1996, 49 (3) : 201-211.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [76808-16-7]