Columbamine

• Description:

  Columbamine (Columbamin; Dehydroisocorypalmine) is an organic heterotetracyclic alkaloid extracted from plants. Columbamine is a metabolite of Berberine (HY-N0716) . Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM) . Columbamine induces apoptosis in cancer cells. Columbamine can be used for antioxidant, anti-inflammatory, antitumor, antifungal, antiparasite, hepatoprotective, neuroprotective, hypolipidemic and hypoglycemic study[1][2][3][4][5].

• Product Name Alternative:

  Columbamin; Dehydroisocorypalmine

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H311, H331

• Target:

  Apoptosis; Cytochrome P450; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Columbamine.html

• Purity:

  99.70

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  COC1=C(OC)C2=C[N+]3=C(C4=CC(O)=C(OC)C=C4CC3)C=C2C=C1

• Molecular Formula:

  C20H20NO4

• Molecular Weight:

  338.38

• Precautions:

  H301, H311, H331

• References & Citations:

  [1]Wright CW, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63 (12) :1638-40.|[2]Cao S, et al. Berberine metabolites exhibit triglyceride-lowering effects via activation of AMP-activated protein kinase in Hep G2 cells. J Ethnopharmacol. 2013 Sep 16;149 (2) :576-82.|[3]Su CR, et al. Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. J Nat Prod. 2007 Dec;70 (12) :1930-3.|[4]Lei C, et al. Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway. Cancer Manag Res. 2019 Sep 23;11:8635-8645.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  CYP3A4

• CAS Number:

  3621-36-1