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Columbamine

CAT: 0804-HY-N0926-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0926-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Columbamine (Columbamin; Dehydroisocorypalmine) is an organic heterotetracyclic alkaloid extracted from plants. Columbamine is a metabolite of Berberine. Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). Columbamine induces apoptosis in cancer cells. Columbamine can be used for antioxidant, anti-inflammatory, antitumor, antifungal, antiparasite, hepatoprotective, neuroprotective, hypolipidemic and hypoglycemic study[1][2][3][4][5].
CAS Number
3621-36-1
Product Name Alternative
Columbamin; Dehydroisocorypalmine
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Apoptosis; Cytochrome P450; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Columbamine.html
Purity
99.70
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C2=C[N+]3=C(C4=CC(O)=C(OC)C=C4CC3)C=C2C=C1
Molecular Formula
C20H20NO4
Molecular Weight
338.38
Precautions
H301, H311, H331
References & Citations
[1]Wright CW, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63 (12) :1638-40.|[2]Cao S, et al. Berberine metabolites exhibit triglyceride-lowering effects via activation of AMP-activated protein kinase in Hep G2 cells. J Ethnopharmacol. 2013 Sep 16;149 (2) :576-82.|[3]Su CR, et al. Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. J Nat Prod. 2007 Dec;70 (12) :1930-3.|[4]Lei C, et al. Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway. Cancer Manag Res. 2019 Sep 23;11:8635-8645.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP3A4

Alternative Products

CatalogName
BUP04703-01Columbamine
AR-C03472-01Columbamine Chloride
MBS1314286-01Recombinant Coptis japonica Columbamine O-methyltransferase

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