Filaggrin (Keratinocyte Differentiation Marker)

• Gene Name:

  [FLG]

• NCBI Gene ID:

  2313

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

• Other Gene Names:

  [FLI1; FLI1; EWSR2; SIC-1; BDPLT21]

• Short Name:

  [Filaggrin]

• Other Product Names:

  [Friend leukemia integration 1 transcription factor isoform 1; Friend leukemia integration 1 transcription factor; Friend leukemia integration 1 transcription factor; Fli-1 proto-oncogene, ETS transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB]

• NCBI GI Number:

  7110593

• NCBI Accession Number:

  NP_002008

• NCBI GB Accession Number:

  NP_002008.2

• Uniprot Accession Number:

  P20930