ZAP70 (Chronic Lymphocytic Leukemia Marker)

• Gene Name:

  [ZAP70]

• NCBI Gene ID:

  7535

• Reactivity:

  Human. Others not known

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

• Other Gene Names:

  [ZAP70; ZAP70; SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70; SRK]

• Short Name:

  [ZAP70]

• Other Product Names:

  [tyrosine-protein kinase ZAP-70 isoform 1; Tyrosine-protein kinase ZAP-70; tyrosine-protein kinase ZAP-70; zeta chain of T cell receptor associated protein kinase 70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase]

• NCBI GI Number:

  31455611

• NCBI Accession Number:

  NP_001070.2

• NCBI GB Accession Number:

  NM_001079.3

• Uniprot Accession Number:

  P43403