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DBC2/RHOBTB2

CAT: 0544-MBS4381672-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
CAT#:0544-MBS4381672-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[RHOBTB2]
NCBI Gene ID
23221
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.
Other Gene Names
[RHOBTB2; RHOBTB2; p83; DBC2; EIEE64; DBC2; KIAA0717]
Short Name
[DBC2/RHOBTB2]
Other Product Names
[DBC2; Rho-related BTB domain-containing protein 2; rho-related BTB domain-containing protein 2; Rho related BTB domain containing 2; Deleted in breast cancer 2 gene protein; p83]
NCBI GI Number
12667516
NCBI Accession Number
AAG61157.1
Uniprot Accession Number
Q9BYZ6

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