Thymidine Phosphorylase/PD-ECGF (Angiogenesis Marker)

Thymidine Phosphorylase/PD-ECGF (Angiogenesis Marker)

• Gene Name: [TYMP]
• NCBI Gene ID: 1890
• Reactivity: Human, Mouse, Rat
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
• Other Gene Names: [TYMP; TYMP; TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF; ECGF1; TP; PD-ECGF]
• Short Name: [Thymidine Phosphorylase/PD-ECGF]
• Other Product Names: [thymidine phosphorylase isoform 1; Thymidine phosphorylase; thymidine phosphorylase; thymidine phosphorylase; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase]
• NCBI GI Number: 166158925
• NCBI Accession Number: NP_001107228.1
• NCBI GB Accession Number: NP_001107228.1
• Uniprot Accession Number: P19971