Thymidine Phosphorylase/PD-ECGF (Angiogenesis Marker)

• Gene Name:

  [TYMP]

• NCBI Gene ID:

  1890

• Reactivity:

  Human, Mouse, Rat. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

• Other Gene Names:

  [TYMP; TYMP; TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF; ECGF1; TP; PD-ECGF]

• Short Name:

  [Thymidine Phosphorylase/PD-ECGF]

• Other Product Names:

  [thymidine phosphorylase isoform 1; Thymidine phosphorylase; thymidine phosphorylase; thymidine phosphorylase; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase]

• NCBI GI Number:

  166158922

• NCBI Accession Number:

  NP_001107227.1

• NCBI GB Accession Number:

  NM_001113755.2

• Uniprot Accession Number:

  P19971