CD137, Mouse

• Gene Name:

  [CD137]

• NCBI Gene ID:

  21942

• Reactivity:

  Mouse
  Does not react with Human.

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.

• Other Gene Names:

  [Tnfrsf9; Tnfrsf9; ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik; Cd137; Ila; Ly63]

• Short Name:

  [CD137]

• Other Product Names:

  [tumor necrosis factor receptor superfamily member 9 isoform 1; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; CD_antigen: CD137]

• NCBI GI Number:

  117422439

• NCBI Accession Number:

  NP_001070977.1

• NCBI GB Accession Number:

  NP_001070977.1

• Uniprot Accession Number:

  P20334