CD74 (B-Cell Marker)

• Gene Name:

  [CD74]

• NCBI Gene ID:

  972

• Reactivity:

  Human, Baboon, Mouse
  Does not react with Rat.

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

• Other Gene Names:

  [CD74; II; p33; DHLAG; HLADG; Ia-GAMMA]

• Short Name:

  [CD74]

• Other Product Names:

  [HLA class II histocompatibility antigen gamma chain; CD74 molecule]

• Uniprot Accession Number:

  P044233