CD33/SIGLEC3 (Myeloid Cell Surface Antigen)

• Gene Name:

  [CD33]

• NCBI Gene ID:

  945

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 4 to 8 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

• Other Gene Names:

  [CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3]

• Short Name:

  [CD33/SIGLEC3]

• Other Product Names:

  [Myeloid cell surface antigen CD33; Myeloid cell surface antigen CD33; myeloid cell surface antigen CD33; CD33 molecule; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33]

• NCBI GI Number:

  116241290

• NCBI Accession Number:

  P20138.2

• Uniprot Accession Number:

  P20138

• CAS Number:

  9007-83-4