CD19 (B-Lymphocyte Marker)

• Gene Name:

  [CD19]

• NCBI Gene ID:

  930

• Reactivity:

  Human

• Storage Conditions:

  Antibody without azide - store at -20 to -80 degrees C. Non-hazardous. No MSDS required.

• Specificity:

  CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.

• Other Gene Names:

  [CD19; CD19; B4; CVID3]

• Short Name:

  [CD19]

• Other Product Names:

  [B-lymphocyte antigen CD19 isoform 1; B-lymphocyte antigen CD19; B-lymphocyte antigen CD19; CD19 molecule; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12]

• NCBI GI Number:

  296010921

• NCBI Accession Number:

  NP_001171569.1

• NCBI GB Accession Number:

  NP_001171569.1

• Uniprot Accession Number:

  P15391