CD8A (Cytotoxic/Suppressor T-Cell Marker)

• Gene Name:

  [CD8A]

• NCBI Gene ID:

  925

• Reactivity:

  Human, Non-Human primates

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  This MAb is specific for the 32kDa alpha chain of human CD8, known as CD8a or CD8 alpha.CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

• Other Gene Names:

  [CD8A; CD8A; CD8; p32; Leu2; MAL]

• Short Name:

  [CD8A]

• Other Product Names:

  [T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2]

• NCBI GI Number:

  225007536

• NCBI Accession Number:

  NP_001139345.1

• NCBI GB Accession Number:

  NP_001139345.1

• Uniprot Accession Number:

  P01732