CD7 (T-Cell Leukemia Marker)

CD7 (T-Cell Leukemia Marker)

• Gene Name: [CD7]
• NCBI Gene ID: 924
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
• Other Gene Names: [CD7; CD7; GP40; TP41; Tp40; LEU-9]
• Short Name: [CD7]
• Other Product Names: [T-cell antigen CD7; T-cell antigen CD7; T-cell antigen CD7; CD7 molecule; GP40; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41; CD_antigen: CD7]
• NCBI GI Number: 5453613
• NCBI Accession Number: NP_006128.1
• NCBI GB Accession Number: NP_006128.1
• Uniprot Accession Number: P09564