CD1c

• Gene Name:

  [CD1C]

• NCBI Gene ID:

  911

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with -2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1

• Other Gene Names:

  [CD1C; CD1C; R7; CD1; CD1A; BDCA1]

• Short Name:

  [CD1c]

• Other Product Names:

  [T-cell surface glycoprotein CD1c; T-cell surface glycoprotein CD1c; T-cell surface glycoprotein CD1c; CD1c molecule; CD_antigen: CD1c]

• NCBI GI Number:

  110618227

• NCBI Accession Number:

  NP_001756.2

• NCBI GB Accession Number:

  NP_001756.2

• Uniprot Accession Number:

  P29017