CD1a/HTA1 (Mature Langerhans Cells Marker)

CD1a/HTA1 (Mature Langerhans Cells Marker)

• Gene Name: [CD1A]
• NCBI Gene ID: 909
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
• Other Gene Names: [CD1A; CD1A; R4; T6; CD1; FCB6; HTA1; hTa1 thymocyte antigen]
• Short Name: [CD1a/HTA1]
• Other Product Names: [T-cell surface glycoprotein CD1a; T-cell surface glycoprotein CD1a; T-cell surface glycoprotein CD1a; CD1a molecule; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a]
• NCBI GI Number: 288558852
• NCBI Accession Number: P06126.4
• Uniprot Accession Number: P06126