CD1a/HTA1 (Mature Langerhans Cells Marker)

• Gene Name:

  [CD1A]

• NCBI Gene ID:

  909

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide - store at 2-8°C.
  Antibody without azide - store at -20 to -80°C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa). 

• Other Gene Names:

  [CD1A; CD1A; R4; T6; CD1; FCB6; HTA1; hTa1 thymocyte antigen]

• Short Name:

  [CD1a/HTA1]

• Other Product Names:

  [T-cell surface glycoprotein CD1a isoform 2; T-cell surface glycoprotein CD1a; T-cell surface glycoprotein CD1a; CD1a molecule; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a]

• NCBI GI Number:

  1002167153

• NCBI Accession Number:

  NP_001307581.1

• NCBI GB Accession Number:

  NM_001320652.1

• Uniprot Accession Number:

  P06126