Thyroid Stimulating Hormone, beta (TSH beta) (Pituitary Marker)

• Gene Name:

  [TSHB]

• NCBI Gene ID:

  7252

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH) follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated non-covalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. TSH is synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). TSH production is controlled by a Thyrotropin-Releasing Hormone (TRH), which is manufactured in the hypothalamus and transported to the pituitary gland, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release. TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

• Other Gene Names:

  [TSHB; TSHB; TSH-B; TSH-BETA; TSH-B; TSH-beta]

• Short Name:

  [Thyroid Stimulating Hormone, beta (TSH beta)]

• Other Product Names:

  [thyrotropin subunit beta isoform 1; Thyrotropin subunit beta; thyrotropin subunit beta; thyroid stimulating hormone subunit beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa]

• NCBI GI Number:

  115430099

• NCBI Accession Number:

  NP_000540.2

• NCBI GB Accession Number:

  NP_000540.2

• Uniprot Accession Number:

  P01222