STAT5B

• Gene Name:

  [STAT5B]

• NCBI Gene ID:

  6777

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

• Other Gene Names:

  [STAT5B; STAT5B; STAT5]

• Short Name:

  [STAT5B]

• Other Product Names:

  [signal transducer and activator of transcription 5B; Signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B]

• NCBI GI Number:

  21618344

• NCBI Accession Number:

  NP_036580.2

• NCBI GB Accession Number:

  NP_036580.2

• Uniprot Accession Number:

  P51692