BRCA1 (Breast Marker)

• Gene Name:

  [BRCA1]

• NCBI Gene ID:

  672

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

• Other Gene Names:

  [BRCA1; BRCA1; IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53; RNF53]

• Short Name:

  [BRCA1]

• Other Product Names:

  [breast cancer type 1 susceptibility protein isoform 1; Breast cancer type 1 susceptibility protein; breast cancer type 1 susceptibility protein; BRCA1 DNA repair associated; RING finger protein 53]

• NCBI GI Number:

  6552299

• NCBI Accession Number:

  NP_009225.1

• NCBI GB Accession Number:

  NP_009225.1

• Uniprot Accession Number:

  P38398