SREBP2

• Gene Name:

  [SREBF2]

• NCBI Gene ID:

  6721

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

• Other Gene Names:

  [SREBF2; SREBF2; SREBP2; bHLHd2; SREBP-2; BHLHD2; SREBP2; SREBP-2; bHLHd2]

• Short Name:

  [SREBP2]

• Other Product Names:

  [sterol regulatory element binding protein-2; Sterol regulatory element-binding protein 2; sterol regulatory element-binding protein 2; sterol regulatory element binding transcription factor 2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2]

• NCBI GI Number:

  451330

• NCBI Accession Number:

  AAA50746.1

• Uniprot Accession Number:

  Q12772