VISTA/GI24 (Negative Regulator of Immune Response)

VISTA/GI24 (Negative Regulator of Immune Response)

• Gene Name: [VISTA/GI24]
• NCBI Gene ID: 64115
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: VISTA/GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30kDa extracellular fragment plus a 25-30kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment). It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy.
• Other Gene Names: [VSIR; C10orf54; B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha; ; Sisp-1]
• Short Name: [VISTA/GI24]
• Other Product Names: [V-type immunoglobulin domain-containing suppressor of T-cell activation; V-type immunoglobulin domain-containing suppressor of T-cell activation; V-type immunoglobulin domain-containing suppressor of T-cell activation; V-set immunoregulatory receptor; Platelet receptor Gi24]
• NCBI GI Number: 62339432
• NCBI Accession Number: NP_071436.1
• NCBI GB Accession Number: NP_071436.1
• Uniprot Accession Number: Q9H7M9