EGLN1/PHD2

• Gene Name:

  [EGLN1]

• NCBI Gene ID:

  54583

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  366G/76/3 recognises human prolyl hydroxylase 2 (PHD2), a 46kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.
  Immunogen sequence has 83% identity with Mouse.

• Other Gene Names:

  [EGLN1; EGLN1; HPH2; PHD2; SM20; ECYT3; HALAH; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; PHD2]

• Short Name:

  [EGLN1/PHD2]

• Other Product Names:

  [Egl nine homolog 1; Egl nine homolog 1; egl nine homolog 1; egl-9 family hypoxia inducible factor 1; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; SM-20]

• NCBI GI Number:

  32129514

• NCBI Accession Number:

  Q9GZT9.1

• Uniprot Accession Number:

  Q9GZT9