Cytochrome C (Mitochondrial Marker)

[CYCS]

54205

Human, Mouse, Rat, Horse, Dog, Pigeon, Frog, Drosophila

Antibody with azide - store at 2 to 8 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

It recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C, a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e. cytochrome in the mitochondria with heme attached).

[CYCS; CYCS; CYC; HCS; THC4; CYC]

[Cytochrome C]

[cytochrome c; Cytochrome c; cytochrome c; cytochrome c, somatic]

11128019

NP_061820.1

NP_061820.1