ORC1

CAT: 0544-MBS4381140-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
CAT#:0544-MBS4381140-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[ORC1]
NCBI Gene ID
4998
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.
Other Gene Names
[ORC1; ORC1; ORC1L; PARC1; HSORC1; ORC1L; PARC1]
Short Name
[ORC1]
Other Product Names
[origin recognition complex subunit 1 isoform 1; Origin recognition complex subunit 1; origin recognition complex subunit 1; origin recognition complex subunit 1; Replication control protein 1]
NCBI GI Number
299890793
NCBI Accession Number
NP_001177747.1
NCBI GB Accession Number
NP_001177747.1
Uniprot Accession Number
Q13415

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