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CD73 (Immuno-Oncology Target)

CAT: 0544-MBS4381131-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
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CAT#:0544-MBS4381131-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[CD73]
NCBI Gene ID
4907
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins.
Other Gene Names
[NT5E; NT5E; NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA; NT5; NTE; 5'-NT]
Short Name
[CD73]
Other Product Names
[5'-nucleotidase; 5'-nucleotidase; 5'-nucleotidase; 5'-nucleotidase ecto; Ecto-5'-nucleotidase; CD_antigen: CD73]
NCBI GI Number
112825
NCBI Accession Number
P21589.1
Uniprot Accession Number
P21589

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Alternative Products

CatalogName
BNUM2545-50CD73 (Immuno-Oncology Target) (NT5E/2545), 1mg/mL
BNUM2646-50CD73 (Immuno-Oncology Target) (NT5E/2646), 1mg/mL
BNUM2503-50CD73 (Immuno-Oncology Target) (NT5E/2503), 1mg/mL
BNUM2505-50CD73 (Immuno-Oncology Target) (NT5E/2505), 1mg/mL
BNUB2646-100CD73 (Immuno-Oncology Target) (NT5E/2646), 0.2mg/mL
BNUB2505-100CD73 (Immuno-Oncology Target) (NT5E/2505), 0.2mg/mL
BNUB2503-100CD73 (Immuno-Oncology Target) (NT5E/2503), 0.2mg/mL
BNUB2545-100CD73 (Immuno-Oncology Target) (NT5E/2545), 0.2mg/mL
36-2876-100Anti-CD73 (Immuno-Oncology Target) Monoclonal Antibody (Clone: NT5E/2503)
36-2879-20Anti-CD73 (Immuno-Oncology Target) Monoclonal Antibody (Clone: NT5E/2646)

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