NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)

NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)

• Gene Name: [NKX3.1]
• NCBI Gene ID: 4824
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
• Other Gene Names: [NKX3-1; NKX3-1; NKX3; BAPX2; NKX3A; NKX3.1; NKX3.1; NKX3A]
• Short Name: [NKX3.1]
• Other Product Names: [homeobox protein Nkx-3.1 isoform 2; Homeobox protein Nkx-3.1; homeobox protein Nkx-3.1; NK3 homeobox 1; Homeobox protein NK-3 homolog A]
• NCBI GI Number: 373432628
• NCBI Accession Number: NP_001243268.1
• NCBI GB Accession Number: NP_001243268.1
• Uniprot Accession Number: Q99801