MSH2 (DNA Mismatch Repair Marker)

MSH2 (DNA Mismatch Repair Marker)

• Gene Name: [MSH2]
• NCBI Gene ID: 4436
• Reactivity: Human
• Storage Conditions: Antibody without azide: store at -20 to -80 degree C.
  Non-hazardous. No MSDS required.
• Specificity: Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
• Other Gene Names: [MSH2; MSH2; FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1; hMSH2]
• Short Name: [MSH2]
• Other Product Names: [DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2; mutS homolog 2; MutS protein homolog 2]
• NCBI GI Number: 1171032
• NCBI Accession Number: P43246.1
• Uniprot Accession Number: P43246