MBD1 (Methyl-CpG Binding Domain Protein 1)

• Gene Name:

  [MBD1]

• NCBI Gene ID:

  4152

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has also been predicted to be involved in the development and progression of tumors, and it has been shown that MBD1 is significantly upregulated in pancreatic cancer tissues when compared with surrounding normal tissues. Furthermore, MBD1 may serve as a potential therapeutic target for pancreatic cancer.

• Other Gene Names:

  [MBD1; MBD1; RFT; PCM1; CXXC3; CXXC3; PCM1]

• Short Name:

  [MBD1 (Methyl-CpG Binding Domain Protein 1)]

• Other Product Names:

  [methyl-CpG-binding domain protein 1 isoform 6; Methyl-CpG-binding domain protein 1; methyl-CpG-binding domain protein 1; methyl-CpG binding domain protein 1; CXXC-type zinc finger protein 3; Methyl-CpG-binding protein MBD1; Protein containing methyl-CpG-binding domain 1]

• NCBI GI Number:

  323462147

• NCBI Accession Number:

  NP_001191065.1

• NCBI GB Accession Number:

  NP_001191065.1

• Uniprot Accession Number:

  Q9UIS9