HLA-DQ (MHC II)

HLA-DQ (MHC II)

• Gene Name: [HLA-DQ]
• NCBI Gene ID: 3117
• Reactivity: Human, Pig
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
• Other Gene Names: [HLA-DQA1; HLA-DQA1; DQA1; DQ-A1; CELIAC1; HLA-DQA]
• Short Name: [HLA-DQ]
• Other Product Names: [HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA class II histocompatibility antigen, DQ alpha 1 chain; major histocompatibility complex, class II, DQ alpha 1; DC-1 alpha chain; DC-alpha; HLA-DCA; MHC class II DQA1]
• NCBI GI Number: 18426975
• NCBI Accession Number: NP_002113.2
• NCBI GB Accession Number: NP_002113.2
• Uniprot Accession Number: P01908