NKX2.8

• Gene Name:

  [NKX2.8]

• NCBI Gene ID:

  26257

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

• Other Gene Names:

  [NKX2-8; NKX2-8; NKX2H; NKX2.8; Nkx2-9; NKX-2.8; NKX2G; NKX2H]

• Short Name:

  [NKX2.8]

• Other Product Names:

  [homeobox protein Nkx-2.8; Homeobox protein Nkx-2.8; homeobox protein Nkx-2.8; NK2 homeobox 8; Homeobox protein NK-2 homolog H]

• NCBI GI Number:

  31377777

• NCBI Accession Number:

  NP_055175

• NCBI GB Accession Number:

  NP_055175.2

• Uniprot Accession Number:

  O15522