NKX2.8 (NKX2-8) (NM_014360) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]

• Synonyms:

  Nkx2-9; NKX2.8; NKX2H

• Gene ID:

  26257

• UniProt:

  O15522

• Accession Number mRNA:

  NM_014360

• Chromosomal Location:

  14q13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  25.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NKX2-8

• Species:

  Human

• Protein ID:

  NP_055175

• Overview:

  Recombinant protein of human NK2 homeobox 8 (NKX2-8)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/26257

• Uniprot URL:

  https://www.uniprot.org/uniprot/O15522

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014360

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055175