Cadherin 17/LI Cadherin (Liver-Intestine Marker)

• Gene Name:

  [CDH17]

• NCBI Gene ID:

  1015

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  It recognizes a protein of 120kDa, which is identified as Cadherin 17 (also known as LI Cadherin). The cadherins are a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.

• Other Gene Names:

  [CDH17; CDH17; HPT1; CDH16; HPT-1; LI-cadherin]

• Short Name:

  [Cadherin 17/LI Cadherin]

• Other Product Names:

  [cadherin-17; Cadherin-17; cadherin-17; cadherin 17; Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin]

• NCBI GI Number:

  221316595

• NCBI Accession Number:

  NP_001138135.1

• NCBI GB Accession Number:

  NP_001138135.1

• Uniprot Accession Number:

  Q12864