CD5 (Mantle Cell LymphomaMarker)

• Gene Name:

  [CD5]

• NCBI Gene ID:

  921

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a mature T-cell neoplasms. Anti-CD5 detection is in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.

• Other Gene Names:

  [CD5; CD5; T1; LEU1; LEU1]

• Short Name:

  [CD5]

• Other Product Names:

  [T-cell surface glycoprotein CD5 isoform 2; T-cell surface glycoprotein CD5; T-cell surface glycoprotein CD5; CD5 molecule; Lymphocyte antigen T1/Leu-1; CD_antigen: CD5]

• NCBI GI Number:

  1080078688

• NCBI Accession Number:

  NP_001333385.1

• NCBI GB Accession Number:

  NM_001346456.1

• Uniprot Accession Number:

  P06127