APEX Nuclease I

• Gene Name:

  [PTPN6]

• NCBI Gene ID:

  328

• Reactivity:

  Human. Others not tested.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  APEX/APE1 is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 and XRCC1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a marker for refractory disease.

• Other Gene Names:

  [APEX1; APEX1; APE; APX; APE1; APEN; APEX; HAP1; REF1; APE; APE1; APEX; APX; HAP1; REF1; APEN; AP endonuclease 1; APE-1]

• Short Name:

  [APEX Nuclease I]

• Other Product Names:

  [DNA-(apurinic or apyrimidinic site) lyase; DNA-(apurinic or apyrimidinic site) lyase; DNA-(apurinic or apyrimidinic site) lyase; apurinic/apyrimidinic endodeoxyribonuclease 1; APEX nuclease; APEN]

• NCBI GI Number:

  346644849

• NCBI Accession Number:

  NP_001231178.1

• NCBI GB Accession Number:

  NM_001244249.1

• Uniprot Accession Number:

  P27695