Desmin (Muscle Cell Marker)

• Gene Name:

  [DES]

• NCBI Gene ID:

  1674

• Reactivity:

  Human, Rat, Hamster, Chicken. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

• Other Gene Names:

  [DES; DES; CSM1; CSM2; CDCD3; CMD1F; LGMD1D; LGMD1E; LGMD2R]

• Short Name:

  [Desmin]

• Other Product Names:

  [desmin; Desmin; desmin; desmin]

• NCBI GI Number:

  55749932

• NCBI Accession Number:

  NP_001918.3

• NCBI GB Accession Number:

  NM_001927.3

• Uniprot Accession Number:

  P17661