Crystallin Alpha B

• Gene Name:

  [CRYAB]

• NCBI Gene ID:

  1410

• Reactivity:

  Human. Others not tested.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into alpha, beta and gamma families, and the beta- and gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. alpha-crystallins consist of three gene products, alphaA-, alphaB- and alphaC-crystallin, which are members of the small heat shock protein family (HSP 20). alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, alpha-crystallins do not renature these proteins. Expression of alphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human alphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of alphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

• Other Gene Names:

  [CRYAB; CRYAB; MFM2; CRYA2; CTPP2; HSPB5; CMD1II; CTRCT16; HEL-S-101; CRYA2; HSPB5; HspB5]

• Short Name:

  [Crystallin Alpha B]

• Other Product Names:

  [alpha-crystallin B chain isoform 1; Alpha-crystallin B chain; alpha-crystallin B chain; crystallin alpha B; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component]

• NCBI GI Number:

  577019571

• NCBI Accession Number:

  NP_001276736.1

• NCBI GB Accession Number:

  NM_001289807.1

• Uniprot Accession Number:

  P02511