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CD40/TNFRSF5/CD40L-Receptor

CAT: 0544-MBS4380521-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
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CAT#:0544-MBS4380521-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[CD40]
NCBI Gene ID
958
Reactivity
Human. Others not known.
Specificity
CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
Other Gene Names
[CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5]
Short Name
[CD40/TNFRSF5/CD40L-Receptor]
Other Product Names
[tumor necrosis factor receptor superfamily member 5 isoform 1; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily member 5; CD40 molecule; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40]
NCBI GI Number
4507581
NCBI Accession Number
NP_001241.1
NCBI GB Accession Number
NM_001250.5
Uniprot Accession Number
P25942

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