StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker)

• Gene Name:

  [STAR]

• NCBI Gene ID:

  6770

• Reactivity:

  Human. Others not known.

• Specificity:

  Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.

• Other Gene Names:

  [STAR; STAR; STARD1; STARD1; StAR; StARD1]

• Short Name:

  [StAR (Steroidogenic Acute Regulator)]

• Other Product Names:

  [steroidogenic acute regulatory protein, mitochondrial; Steroidogenic acute regulatory protein, mitochondrial; steroidogenic acute regulatory protein, mitochondrial; steroidogenic acute regulatory protein; START domain-containing protein 1; StARD1]

• NCBI GI Number:

  56243551

• NCBI Accession Number:

  NP_000340.2

• NCBI GB Accession Number:

  NM_000349.2

• Uniprot Accession Number:

  P49675