PU.1 (SPI-1) (B-Cell Marker)

• Gene Name:

  [PU.1]

• NCBI Gene ID:

  6688

• Reactivity:

  Human. Others not known.

• Specificity:

  PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.

• Other Gene Names:

  [SPI1; SPI1; OF; PU.1; SFPI1; SPI-1; SPI-A]

• Short Name:

  [PU.1 (SPI-1)]

• Other Product Names:

  [transcription factor PU.1 isoform 1; Transcription factor PU.1; transcription factor PU.1; Spi-1 proto-oncogene; 31 kDa-transforming protein]

• NCBI GI Number:

  124028521

• NCBI Accession Number:

  NP_001074016.1

• NCBI GB Accession Number:

  NM_001080547.1

• Uniprot Accession Number:

  P17947