Perforin-1 (Pore Forming Protein) (Apoptosis Marker)

Perforin-1 (Pore Forming Protein) (Apoptosis Marker)

• Gene Name: [PRF1]
• NCBI Gene ID: 5551
• Reactivity: Human. Others not known.
• Storage Conditions: Antibody with azide store at 2-8°C.
  
  Antibody is stable for 24 months. Non hazardous. No msds requiresd.
• Specificity: Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
• Other Gene Names: [PRF1; PRF1; P1; PFP; HPLH2; PFP; P1; PFP]
• Short Name: [Perforin-1]
• Other Product Names: [perforin-1; Perforin-1; perforin-1; perforin 1; Cytolysin; Lymphocyte pore-forming protein; PFP]
• NCBI GI Number: 133908621
• NCBI Accession Number: NP_001076585.1
• NCBI GB Accession Number: NM_001083116.2
• Uniprot Accession Number: P14222