Ki-67 (Proliferating Cell Marker)

Ki-67 (Proliferating Cell Marker)

• Gene Name: [Ki-67]
• NCBI Gene ID: 4288
• Reactivity: Human. Others not known.
• Specificity: Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.
• Other Gene Names: [MKI67; MKI67; KIA; MIB-; MIB-1; PPP1R105; Antigen KI-67Curated; Antigen Ki67Curated]
• Short Name: [Ki-67]
• Other Product Names: [proliferation marker protein Ki-67 isoform 2; Proliferation marker protein Ki-67; proliferation marker protein Ki-67; marker of proliferation Ki-67; Antigen identified by monoclonal antibody Ki-67]
• NCBI GI Number: 225543215
• NCBI Accession Number: NP_001139438.1
• NCBI GB Accession Number: NM_001145966.1
• Uniprot Accession Number: P46013