CD25/ IL2RA (Activated Lymphocyte Marker)

• Gene Name:

  [CD25]

• NCBI Gene ID:

  3559

• Reactivity:

  Human. Others not tested.

• Specificity:

  Recognizes a protein of 55kDa, identified as CD25.It is expressed on activated T- and B-cells and activated monocytes/macrophages.With respect to lymphomas, CD25 is present on malignant cells of Hodgkins disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R  chain, p75) and CD132 (common chain) to form the high affinity IL-2 receptor complex.CD25 antibodies detect three epitope regions, A, B and C. This MAb recognizes the epitope B, which is located at residue 3-104 of CD25 and doe not block IL-2 binding to CD25.

• Other Gene Names:

  [IL2RA; IL2RA; p55; CD25; IL2R; IMD41; TCGFR; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA]

• Short Name:

  [CD25/ IL2RA]

• Other Product Names:

  [interleukin-2 receptor subunit alpha isoform 1; Interleukin-2 receptor subunit alpha; interleukin-2 receptor subunit alpha; interleukin 2 receptor subunit alpha; TAC antigen; p55; CD_antigen: CD25]

• NCBI GI Number:

  4557667

• NCBI Accession Number:

  NP_000408.1

• NCBI GB Accession Number:

  NP_000408.1

• Uniprot Accession Number:

  P01589